Antibiotic Resistance

I think that the evolution of antibiotic resistance is an interesting and important issue. Below I has listed the expected learning outcomes for this topic in BIOL 1404. Because this topic has widespread medical relevance I have included a lot of additional readings and a powerpoint presentation that I developed for another class last semester. This info is not required, but is only intended to provide more info to interested students.

Expected Learning Outcomes

By the end of the course a fully engaged students should be able to

- discuss the causes of the development of antibiotic resistance

- discuss where antibiotics come from

- discuss what we have learned from ecology and evolutionary biology about potentila problems associated with antibiotic use

- discuss what we have learned from evolutionary biology that should help us fight microbial diseases more effectively

Past Exam Questions (answers at the bottom of the post)

In the 1950s, Japanese physicians began to notice that some hospital patients suffering from bacterial dysentery, which produces severe diarrhea, did not respond to antibiotics that had generally been effective in the past.

1. In order for the result described above to have occurred, which of the following must have been true in the population of dysentery-causing bacteria?
(a) there was variation in the susceptibility of the bacteria to antibiotics
(b) antibiotic resistance was heritable
(c) bacteria that were more resistant to antibiotics had higher survival rates than less resistant bacteria
(d) a, b, and c
(e) neither a, b, or c was true


2. What can be done in future to limit the problem of antibiotic resistance in disease-causing microorganisms?
(a) Doctors should only describe antibiotics when appropriate
(b) Doctors should prescribe larger doses of antibiotics
(c) patients should make sure to take all of the pills when antibiotics are prescribed
(d) a and c
(d) a, b, and c

Answers 1. d 2. d

Further Reading

Evolution of Antibiotic Resistance-
http://www.pbs.org/wgbh/evolution/library/10/4/l_104_03.html

Antibiotic resistance: Questions and Answers- CDC
http://www.cdc.gov/getsmart/antibiotic-use/anitbiotic-resistance-faqs.html

Antibiotic resistance- delaying the inevitable (parts 1 and 2) UC Berkeley
http://evolution.berkeley.edu/evosite/relevance/IA1antibiotics2.shtml

HIV the ultimate evolver (parts 1-3) UC Berkeley
http://evolution.berkeley.edu/evosite/relevance/IA2HIV.shtml

Resisting our drugs-
http://understandingevolution.com/evolibrary/article/0_0_0/bergstrom_03

Turbochared evolution-
http://understandingevolution.com/evolibrary/article/side_0_0/turboevolution_01

Relevance of evolution:medicine-
http://understandingevolution.com/evolibrary/article/0_0_0/medicine_01

Powerpoint Presentation

Here is a link the the powerpoint presentation I used in that class.

http://www.slideshare.net/secret/rPekyBdLalUvFY